Aggregation polymorphism of photoactivatable Pt(IV) prodrugs as a strategy for the design of theranostic nanomaterials

Vladislav Bykusov; Ilia Kuzmichev; Maxim Stepanov; Dmitry Bunin; Yuriy Luponosov; Yulia Isaeva; Askold Trul; Roman Akasov; Tatiana Egorova; Alexander Erofeev; Regina Kuanaeva; Yulia Maksimova; Maxim Abakumov; Aleksey Nikitin; Vladimir Kuzmin; Anton Egorov; Ivan Burtsev; Igor A. Rodin; Mikhail F. Vokuev; Elena Beloglazkina; Olga Krasnovskaya

doi:10.1039/D5DT02973B

Aggregation polymorphism of photoactivatable Pt(iv) prodrugs as a strategy for the design of theranostic nanomaterials

Vladislav Bykusov,†^a Ilia Kuzmichev,†^ab Maxim Stepanov,^c Dmitry Bunin,^d Yuriy Luponosov,^e Yulia Isaeva,^ae Askold Trul,

^e Roman Akasov,

^e Tatiana Egorova,^c Alexander Erofeev,

^f Regina Kuanaeva,^af Yulia Maksimova,

^g Maxim Abakumov,

^bf Aleksey Nikitin,^f Vladimir Kuzmin,

^h Anton Egorov,^h Ivan Burtsev,^h Igor A. Rodin,

^a Mikhail F. Vokuev,

^a Elena Beloglazkina

^a and Olga Krasnovskaya

†*^a

Author affiliations

* Corresponding authors

^a Lomonosov Moscow State University, Chemistry Department, Leninskie Gory 1-3, Moscow, Russia
E-mail: Krasnovskayao@gmail.com

^b Department of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, Ostrovityanova Str., 1, 6, Moscow, Russia

^c Moscow Pedagogical State University (MPGU), 29/7 Malaya Pirogovskaya Str., Building 1, Moscow, Russia

^d Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences, 31-4, Leninsky Prospect, 119071 Moscow, Russia

^e Enikolopov Institute of Synthetic Polymer Materials RAS, Profsoyuznaya St. 70, Moscow, Russia

^f National University of Science and Technology (MISIS), Leninskiy Prospect 4, Moscow, Russia

^g Geological Institute of the Russian Academy of Sciences, Pyzhevsky Per., 7, Building 1, Moscow, Russia

^h Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygina Str., b. 4, Moscow, Russia

Abstract

The design of multifunctional theranostic nanomaterials, including the application of J-aggregates as photothermal (PTT) and photodynamic (PDT) therapy agents, is in high demand. Here, we report J-aggregates based on two photoactivatable Pt(IV) prodrugs NO₂-Pt and C₆F₅-Pt with acceptor BODIPYs in the axial position with the A–A–D structure, capable of photoinduced cisplatin release in addition to PDT and PTT activity. Fluorophores showed aggregation polymorphism depending on the solvent used; non-fluorescent CT-coupled J-aggregates with a small bathochromic shift and fluorescent slip-stacked J-aggregates with a high bathochromic shift were isolated and characterized.

These data represent an important study of the influence of the fluorophore structure on the photophysical properties of J-aggregates and demonstrate the possibility of designing theranostic agents based on photoactivated Pt(IV) prodrugs.

Graphical abstract: Aggregation polymorphism of photoactivatable Pt(iv) prodrugs as a strategy for the design of theranostic nanomaterials

Dalton Transactions

Aggregation polymorphism of photoactivatable Pt(iv) prodrugs as a strategy for the design of theranostic nanomaterials

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Aggregation polymorphism of photoactivatable Pt(IV) prodrugs as a strategy for the design of theranostic nanomaterials

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