Commit: Digital pipette: open hardware for liquid transfer in self-driving laboratories

Abstract

Precise liquid handling is an essential operation for self-driving laboratories. In 2023, we introduced the digital pipette, a low-cost, 3D-printed device that enables accurate liquid transfer by robotic arms. However, the initial version lacked mechanisms to prevent cross-contamination when handling multiple liquids. In this commit paper, we present the digital pipette v2, an updated design that mitigates contamination risk by allowing robotic arms to exchange pipette tips. The new hardware achieves liquid handling accuracy within the permissible error range defined by ISO 8655-2, supporting a broader range of experiments involving multiple liquids.

Graphical abstract: Commit: Digital pipette: open hardware for liquid transfer in self-driving laboratories

Article information

Article type
Technical Note
Submitted
31 Jul 2025
Accepted
07 Nov 2025
First published
19 Nov 2025
This article is Open Access
Creative Commons BY license

Digital Discovery, 2026, Advance Article

Commit: Digital pipette: open hardware for liquid transfer in self-driving laboratories

N. Yoshikawa, K. Angers, K. Darvish, S. Okhovatian, D. Bannerman, I. Yakavets, M. Radisic and A. Aspuru-Guzik, Digital Discovery, 2026, Advance Article , DOI: 10.1039/D5DD00336A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements