Electrochemical deoxygenative sulfenylation of aminopyrazoles with sodium sulfinates

Abstract

An electrochemical deoxygenative sulfenylation strategy has been developed, employing odorless sodium sulfinates as the sulfenylation reagents. This method has been successfully applied to the synthesis of aminopyrazole thioether derivatives with moderate to good yields. The protocol exhibits broad functional group tolerance and is readily scalable. Compared with traditional sulfenylation reagents for C–S bond formation, the use of sodium sulfinates offers distinct advantages in terms of operational simplicity and user-friendliness under electrochemical conditions.