From the journal:

Chemical Communications

Visualizing NO2-/NAD(P)H metabolic crosstalk in E. coli-infected bladder cancer via a dual-responsive probe

Jiayun Guan,   Xusheng Jiang,   Yilin Lv,   Yajin Xue,   Jingyi Zhang,   Haiwei Ji,   Guo Li,   Xiaobo Zhou,   Minfeng Yang  and  Qi Wang  

Abstract

A dual-responsive fluorescent probe was developed for real-time monitoring of NO2- and NAD(P)H dynamics. Imaging reveals an E. coli-driven metabolic feedforward loop in bladder cancer, whereby bacteria-derived NO2- upregulates host NAD(P)H, hyperactivating glycolysis and accelerating tumor proliferation.

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Article information

DOI
https://doi.org/10.1039/D6CC02834A
Article type
Communication
Submitted
07 May 2026
Accepted
27 Jun 2026
First published
29 Jun 2026

Chem. Commun., 2026, Accepted Manuscript

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Visualizing NO2-/NAD(P)H metabolic crosstalk in E. coli-infected bladder cancer via a dual-responsive probe

J. Guan, X. Jiang, Y. Lv, Y. Xue, J. Zhang, H. Ji, G. Li, X. Zhou, M. Yang and Q. Wang, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC02834A

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