Palladium-catalyzed regioselective hydrofunctionalization of methylenecyclopropanes (MCPs) with azaaryl alcohols as latent C(sp3 )-nucleophiles

Abstract

Herein, we report a palladium-catalyzed regioselective hydrofunctionalization of methylenecyclopropanes (MCPs). The reaction uses azaaryl alcohols as as methyl azaarene surrogates, proceeds smoothly with a wide variety of mono- and di-substituted MCPs. A range of terminal alkene fragments were introduced to the α-carbon of azaarenes successfully. The reaction is featured with good yeilds, high regioselectivity, and broad substrate scope.