Palladium-catalyzed Asymmetric Carbofluorination of gem-Difluorostyrenes with Cesium Fluoride and Allylic Acetates

Abstract

Palladium-catalyzed asymmetric carbofluorination of difluorostyrenes with allylic acetates and CsF gives synthetically versatile products with a trifluoromethyl, a vinyl and two different aryl groups directly attached to a scaffold exhibiting vicinal chirality centers in good yields and with high stereoselectivities. The synthetic usefulness is highlighted with the incorporation of additional functionalities and the formation of products displaying four adjacent chirality centers, a rarely reported accomplishment.