Catalytic Enantioselective Access to N(III)-Stereogenic Aziridines via Chiral Brønsted Acid-Catalyzed N–Cl Bond Formation

Abstract

The asymmetric construction of nitrogen-centered stereogenicity remains one of the longstanding challenges in asymmetric catalysis. Herein, we report an enantioselective synthesis of N-stereogenic aziridines through a chiral phosphoric acid-catalyzed asymmetric N-chlorination, enabling the efficient construction of chiral N(III)-stereogenic aziridines under mild conditions.