Cooperative organelle targeting from a single molecular module: sterically hindered phenol–diaminopyridine–functionalized cycloalkynes for mitochondria–endoplasmic reticulum localization

Abstract

A modular approach for dual organelle targeting is developed using sterically hindered phenol–diaminopyridine–oxaazacyclononyne (SHP–DAP–OACN) thiourea-linked hybrids. These hybrids retain high reactivity in strain-promoted azide–alkyne cycloaddition, providing fluorescent triazoles with mitochondria and endoplasmic reticulum localization, suggesting SHP–DAP as a transferable module for organelle-directed probes.