Ligand-Controlled, Tunable Palladium-Catalyzed Carbonylation of Thianthrenium Salts and Formic Acids

Abstract

We report a ligand-controlled palladium-catalyzed carbonylation of thianthrenium salts employing HCOOH or DCOOD as a CO source. This divergent method enables the synthesis of (deuterated) aromatic aldehydes, aromatic or alkenyl carboxylic acids, and aromatic esters in good yields. It enables synthesis of medicinally relevant molecules and late-stage functionalization of biorelevant compounds.