Human Tat-Derived Cyclic Peptide Destabilizes the MALAT1 ENE Triple Helix and Attenuates Expression

Abstract

Herein, we report the development of a cyclic peptide targeting the 3′-end ENE triple helix of the metastatic long non-coding RNA MALAT1. The peptide selectively binds and destabilizes the RNA triple helix, surpasses its linear analog, reduces MALAT1 levels, disrupts spheroid morphogenesis, and induces apoptosis in A549 lung cancer cells.