Inhibition of Mincle signaling by chemically synthesized disaccharide-type 6-O-acylated steryl β-glucosides (βASGs) and their analogues derived from plants

Abstract

Chemically synthesized disaccharide βASGs from Dioscorea cayenensis and analogues effectively block Mincle-mediated signaling. This Mincle signaling inhibition requires a disaccharide backbone with sterol and fatty acid moieties, suggesting these glycolipids as key structural templates for developing novel antiinflammatory therapeutics targeting this C-type lectin receptor.