Unravelling the influence of human serum environment on drug release from nanoformulations with polyethylene glycol shell

Abstract

Nano-bio interactions remain underexplored for their impact on drug release profiles of polymeric nanoparticles. Core-shell nanoformulations from linear (PEG-b-PCL) and branched (PEG2-b-PCL) polymers containing a multi-potent drug interact with human serum proteins. These interactions are affected by PEG shell density, leading to enhanced lipophilic cargo release without drug aggregation.