Chirality Transfer to Achiral Strands and Helicity Control through Selective Heteroleptic Complexation to Double-Helical Monometallofoldamers

Abstract

Highly selective construction of heteroleptic double helices was achieved by utilizing bulky substituents to destabilize homoleptic complexation. This strategic design enables efficient chirality transfer to an achiral strand and solvent-dependent helicity inversion, achieving a twofold amplification of the total chiroptical output that far surpasses our previous system.