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We describe the evolution and characterization of a fluorescent light-up aptamer, RhoBAST G36C , that binds asymmetric, rotationally quenched rhodamines. Binding induces an over 300-fold fluorescence turn-on, which we leveraged for real-time monitoring in vitro transcription reactions and live-cell imaging of tRNA and mRNA in E. coli.
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F. Grün, D. Englert, A. Crenner, S. Jänner, E. Burger, M. Sunbul and A. Jaeschke, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC01648K
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