Rational Engineering of Highly Sensitive and Specific Tyrosinase probe for Guiding Melanoma Surgical Resection

Abstract

The precise detection of tyrosinase activity is crucial for the surgical resection of melanoma. Herein, an novel tyrosinase probe (SCy-tyr) was developed to overcome the limitations of poor selectivity and low activation efficiency associated with existing methods. This probe enables highly sensitive and specific imaging of tyrosinase in living cells within 50 minutes, providing a new tool for precise imaging and surgical resection of melanoma.