HSC-targeted nanoplatform for cascade-responsive imaging of mitochondrial H2O2-viscosity and synergistic melatonin-based antioxidant therapy in hepatic ischemia-reperfusion injury

Yiru Wang; Yichen Liu; Yuting Sheng; Wen Zhang; Xin Wang; Hui Wang; Wei Zhang; Ping Li

doi:10.1039/D6CC01621A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

HSC-targeted nanoplatform for cascade-responsive imaging of mitochondrial H₂O₂-viscosity and synergistic melatonin-based antioxidant therapy in hepatic ischemia-reperfusion injury

Yiru Wang,†^a Yichen Liu,†^c Yuting Sheng,†^a Wen Zhang,

*^a Xin Wang,

^a Hui Wang,^a Wei Zhang^a and Ping Li

*^ab

Author affiliations

* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institutes of Biomedical Sciences, Shandong Normal University, Jinan 250014, Shandong, People's Republic of China
E-mail: lip@sdnu.edu.cn, zhangwen@sdnu.edu.cn

^b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, People's Republic of China

^c Aulin College, Northeast Forestry University, Harbin 150040, People's Republic of China

Abstract

We developed an HSC-targeted nanoplatform integrating a mitochondrial H₂O₂/viscosity cascade-responsive fluorescent probe with melatonin, enabling real-time imaging of H₂O₂/viscosity dynamics in HSC during hepatic ischemia-reperfusion injury and simultaneous ROS scavenging to mitigate liver injury, offering a cell-specific theranostic tool.

Download options Please wait...

Supplementary files

Supplementary information PDF (2723K)

Article information

DOI: https://doi.org/10.1039/D6CC01621A
Article type: Communication
Submitted: 18 Mar 2026
Accepted: 20 Apr 2026
First published: 24 Apr 2026

Download Citation

Chem. Commun., 2026, Advance Article

Permissions

Request permissions

HSC-targeted nanoplatform for cascade-responsive imaging of mitochondrial H₂O₂-viscosity and synergistic melatonin-based antioxidant therapy in hepatic ischemia-reperfusion injury

Y. Wang, Y. Liu, Y. Sheng, W. Zhang, X. Wang, H. Wang, W. Zhang and P. Li, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC01621A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Chemical Communications

HSC-targeted nanoplatform for cascade-responsive imaging of mitochondrial H₂O₂-viscosity and synergistic melatonin-based antioxidant therapy in hepatic ischemia-reperfusion injury

Abstract

Supplementary files

Article information

Download Citation

Permissions

HSC-targeted nanoplatform for cascade-responsive imaging of mitochondrial H₂O₂-viscosity and synergistic melatonin-based antioxidant therapy in hepatic ischemia-reperfusion injury

Social activity

Search articles by author

Spotlight

Advertisements