Mechanochemically-synthesised AIE-active receptors for selective ceftazidime sensing in high-water-content matrices

Abstract

Mechanochemical synthesis of water-insoluble, AIE-active dendritic receptors enable selective fluorescence detection of ceftazidime in up to 99 vol% water. Selectivity over structurally related β-lactams was confirmed by titrations, DFT, and NMR studies. Detection remains reliable in tap water, artesian groundwater, and seawater, with a limit of detection (LOD) as low as 1.1 µM.