Synthesis of Fluorinated 1,2-Naphthoquinones from o-Trifluoromethylbenzylamines via Defluorinative Approach
Abstract
A highly efficient and mild defluorinative methodology has been developed to synthesize various fluorinated 1,2-naphthoquinones from readily accessible o-trifluoromethylbenzylamine derivatives and enolizable esters. The resultant fluorinated 1,2-naphthoquinones are subsequently transformed into tetra-substituted indane and phenazine derivatives.
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