From the journal:

Chemical Communications

A prodigiosin-based whole-cell biosensor for sensitive colorimetric detection of Hg(ii)

Peishuo Cao,†ab   Yan Guo,†*bd   Jingwen Ling,c   Jiao Bai,b   Xueqin Yang,b   Liang Zhou*a  and  Chang-ye Hui ORCID logo *bd  

* Corresponding authors

a Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, China
E-mail: zhzliang@smu.edu.cn

b Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, China
E-mail: yanguo615@163.com, hcy_sypu@hotmail.com

c School of Public Health, Shenzhen University, Shenzhen, China

d School of Public Health, Southern Medical University, Guangzhou, China

Abstract

A whole-cell biosensor based on prodigiosin was developed for Hg(II) detection by screening four PigC homologs. The optimized sensor exhibited a detection limit of 0.41 nM, absolute selectivity against competing metal ions, and robust performance in tap, lake, and seawater matrices, providing a sensitive platform for environmental mercury monitoring.

Graphical abstract: A prodigiosin-based whole-cell biosensor for sensitive colorimetric detection of Hg(ii)

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Article information

DOI
https://doi.org/10.1039/D6CC01432A
Article type
Communication
Submitted
10 Mar 2026
Accepted
15 Apr 2026
First published
22 Apr 2026

Chem. Commun., 2026, Advance Article

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A prodigiosin-based whole-cell biosensor for sensitive colorimetric detection of Hg(II)

P. Cao, Y. Guo, J. Ling, J. Bai, X. Yang, L. Zhou and C. Hui, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC01432A

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