Merging deoxygenation with acyl migration process: photoredox-catalyzed synthesis of α-amido-α-(hetero)aryl-1,4-diketones

Abstract

Herein, a new acyl radical addition/acyl migration cascade protocol has been successfully developed. Using PPh3 as O-transfer reagent, a variety of (hetero)aryl carboxylic acids could serve as acyl radical precursors to react with enimides. This procedure dealing with the preparation of α-amido-α-(hetero)aryl-1,4-diketone features broad substrate scopes, good functional group tolerance, and mild reaction conditions.