Thiosulfonate synthesis via halothiolation of aryne intermediates followed by oxidative S-sulfonylation

Abstract

An efficient method for preparing aryl thiosulfonates through aryne intermediates is disclosed. Following aryne halothiolation with potassium xanthate, the resulting aryl xanthates were transformed into thiosulfonates using iodine and sodium sulfinates. The versatility of thiosulfonates together with divergent aryne precursors enabled the access to a wide range of highly functionalized organosulfur compounds.