Next-generation multimetal complex induces immunogenic cell death with distinct transcriptomic signatures

Abstract

Reported here is a Pt(IV)–Au(I)-gemcitabine prodrug that co-releases oxaliplatin, a redox active gold N-heterocyclic carbene (NHC) and gemcitabine upon intracellular reduction. Reative to its constituents, this prodrug displays improved cytotoxicity, metal uptake and an in-vitro immunogenic cell death response.