Copper-catalyzed synthesis of 2‑substituted quinolines via transmetalation/cyclization of (E)-2-(2-(trimethylsilyl)vinyl)-anilines and aldehydes

Abstract

Herein, we have unveiled a novel and efficient tandem strategy for the synthesis of highly diverse 2-substituted quinolines through a copper-catalyzed transmetalation reaction followed by cyclization of (E)-2-(2-(trimethylsilyl)vinyl)anilines with aldehydes. Post-synthetic Rh(III)-catalyzed annulation affords highly fluorescent tetracyclic ammonium salts. Later, photophysical investigations confirm strong emission properties of these tetracyclic frameworks.