From the journal:

Chemical Communications

Boosting the oxidase-mimicking activity of metal–organic framework nanozymes via heteroatom modulation in the organic linkers

Yan Wei,†a   Qiming Yan,†b   Zizhe Yan,a   Jinle Yang,a   Liuhan Zhang,a   Feng Li ORCID logo *a  and  Dangqiang Zhu*ac  

* Corresponding authors

a College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, People's Republic of China
E-mail: zhudq@qau.edu.cn, lifeng@qau.edu.cn

b School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, People's Republic of China

c Key Laboratory of Flexible Optoelectronic Chemical Materials and Devices, Ministry of Education, Jianghan University, Wuhan 430056, People's Republic of China

Abstract

By replacing the linear terephthalate linker with five-membered heterocyclic analogues, we synthesized a series of MIL-53(Fe) nanozymes. The incorporated heteroatoms (O or S) effectively modulate the electron density of the metal active sites. Consequently, the MIL-53(Fe)-TDC variant exhibits an approximately six-fold enhancement in oxidase-like activity compared to its counterpart MIL-53(Fe)-BDC.

Graphical abstract: Boosting the oxidase-mimicking activity of metal–organic framework nanozymes via heteroatom modulation in the organic linkers

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Article information

DOI
https://doi.org/10.1039/D6CC01013J
Article type
Communication
Submitted
15 Feb 2026
Accepted
01 Apr 2026
First published
10 Apr 2026

Chem. Commun., 2026, Advance Article

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Boosting the oxidase-mimicking activity of metal–organic framework nanozymes via heteroatom modulation in the organic linkers

Y. Wei, Q. Yan, Z. Yan, J. Yang, L. Zhang, F. Li and D. Zhu, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC01013J

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