Iridium-Catalyzed Intramolecular Asymmetric Allylic Amination of Anthranilic Acid Derivatives: Enantioselective Construction of Chiral Benzodiazepinones

Abstract

The intramolecular asymmetric allylic amination of anthranilic acidderived allylic carbonates was realized for the first time in high yields (up to 99%) with good enantioselectivities (up to 97% ee) using an iridium catalyst with the chiral-bridged biphenyl phosphoramidite ligand L1, which efficiently accesses a class of chiral benzodiazepinones with a wide range of tolerance to different substituents, further demonstrating the powerful capability of chiral-bridged biphenyl phosphoramidite ligands in asy1mmetric catalysis.