Multiplexed Self-Powered Biosensor for Ultrasensitive On-Site Detection of Trace Cisplatin via Catalytic Repurposing

Abstract

We develop a multiplexed self-powered cisplatin sensor based on catalytic repurposing. Cisplatin is reengineered as a catalyst, amplifying dual-output signals of electrical and smartphone-readable colorimetric outputs. Sensitivity increases 1,000-fold with a broad range (200 nM–100 μM). Dual-output cross-validation yields results matching ICP-MS. This provides a field-deployable platform for precise drug monitoring.