A responsive Co(ii) 19F PARAShift probe: activation of Fermi contact interactions triggered by pH-dependent coordination changes
Kathleen M.
Scott, 
†a
Rahul T.
Kadakia,
†a
Christopher D.
Hastings,
a
Georgia E. F.
Barone,
a
Jackson A.
Reyna,
a
Jin
Xiong,
*b
Yisong
Guo
b
and
Emily L.
Que
*a
†a
Rahul T.
Kadakia,
†a
Christopher D.
Hastings,
a
Georgia E. F.
Barone,
a
Jackson A.
Reyna,
a
Jin
Xiong,
*b
Yisong
Guo
b
and
Emily L.
Que
*a
Abstract
We report a novel 19F MR imaging probe CoNO2ASF5 exhibiting a large 19F chemical shift change of over 30 ppm in response to physiological pH changes. Calculations identify Fermi contact interactions drastic as the mechanism of enhanced 19F MR shift.
- This article is part of the themed collection: 2026 Pioneering Investigator Collection
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