We show that solvent selection plays a decisive role in chiral resolution of RS-phenprocoumon-quinidine. In particular, formation of a bis-acetone solvate suppresses solid solution formation, and affords spontaneous enantioselective crystallization of S-phenprocoumon with enantiomeric excesses of up to 92% in a single resolution step.
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Y. Jiang, S. Souare, F. Leng, T. Leyssens, K. Robeyns and L. Collard, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00933F
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