Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

Azaria C. Razieh; Harry C. Sample; Emily B. Hobson; Anja Mueller; Timothy J. Prior; Carl Redshaw

doi:10.1039/D6CC00888G

Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

Azaria C. Razieh,

†^a Harry C. Sample,

†^a Emily B. Hobson,^b Anja Mueller,^b Timothy J. Prior

^c and Carl Redshaw

*^bd

Author affiliations

* Corresponding authors

^a Department of Chemistry & Biochemistry, University of Hull, Hull, UK

^b School of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich NR4 7TJ, UK

^c Department of Chemistry, University of Liverpool, Crown Street, Liverpool, UK

^d Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 Minami Osawa, Hachioji, Tokyo, Japan
E-mail: credshaw@tmu.ac.jp

Abstract

From reactions of M(OAc)₂·nH₂O (M = Cu, Mn) or Cu(NO₃)₂·3H₂O with p-methyl-N,N′-dimethyldiazacalix[4]areneH₄ (p-MeLH₄) under aerobic conditions, rare examples of azacalixarene-3d-metal complexes were isolated. These, thermally stable non-toxic compounds (≤µM IC₅₀ values) were screened as catalysts for the ring opening polymerization of the cyclic esters ε-caprolactone (ε-CL) and δ-valerolactone (δ-VL) affording low molecular weight cyclic or linear (H/OH end group) polymers. The Mn-based system exhibited the higher activity.

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DOI: https://doi.org/10.1039/D6CC00888G
Article type: Communication
Submitted: 10 Feb 2026
Accepted: 08 Apr 2026
First published: 14 Apr 2026
This article is Open Access

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Chem. Commun., 2026, Advance Article

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Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

A. C. Razieh, H. C. Sample, E. B. Hobson, A. Mueller, T. J. Prior and C. Redshaw, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00888G

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Chemical Communications

Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

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Copper and manganese diazacalix[4]arene complexes: structural and cytotoxicity studies and use in ring opening polymerization of ε-caprolactone and δ-valerolactone

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