From the journal:

Chemical Communications

Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles

Farhad Ali. Mohammed, ORCID logo ab   Hua Tong,a   Chris S. Hawes, ORCID logo c   Shayon Bhattacharya, ORCID logo bd   Damien Thompson, ORCID logo be   Katrina A. Jolliffe ORCID logo f  and  Robert B. P. Elmes ORCID logo *abg  

* Corresponding authors

a Department of Chemistry, Maynooth University, National University of Ireland, Maynooth, Co, Kildare, Ireland
E-mail: robert.elmes@mu.ie

b SSPC – the Research Ireland Centre for Pharmaceuticals, University of Limerick, Limerick, Ireland

c School of Chemical and Physical Sciences, Keele University, Keele, UK

d Department of Biological Sciences, Bernal Institute, University of Limerick, Limerick, Ireland

e Department of Physics, Bernal Institute, University of Limerick, Limerick, Ireland

f ARC Centre of Excellence for Innovations in Peptide and Protein Science, School of Chemistry, University of Sydney, NSW, Australia

g Kathleen Lonsdale Institute for Human Health Research, Maynooth University, National University of Ireland, Co. Kildare, Maynooth, Ireland

Abstract

We report a new class of sequence-defined peptidomimetic macrocycles, termed squaratides, that incorporate squaramide units into a tunable peptide backbone. These modular receptors can bind acetate and chloride ions where sidechain functionality can control affinity and stoichiometry.

Graphical abstract: Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles

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Article information

DOI
https://doi.org/10.1039/D6CC00836D
Article type
Communication
Submitted
13 Feb 2026
Accepted
25 Mar 2026
First published
26 Mar 2026
This article is Open Access
Creative Commons BY license

Chem. Commun., 2026, Advance Article

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Squaratides: a tunable platform for anion binding in peptide-inspired macrocycles

F. Ali. Mohammed, H. Tong, C. S. Hawes, S. Bhattacharya, D. Thompson, K. A. Jolliffe and R. B. P. Elmes, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00836D

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