Fabrication of a Self-Assembling Peptide for the Inhibition of Cancer Cell Proliferation by Targeting LAT1

Abstract

Self-assembling peptides targeting overexpressed proteins and/or enzymes on the cancer cell membrane have emerged as promising strategies for effective and selective cancer therapy. We developed a self-assembling peptide targeting L-type amino acid transporter (LAT1), LffVLKK-4Phe, that selectively inhibits cancer cell proliferation by inhibiting LAT1. This work demonstrates a self-assembling peptide-based strategy to inhibit cancer cell proliferation via suppressing amino acid transport.