A Direct Route to Ynones: Pd-Catalyzed Sonogashira Carbonylative Coupling of Ethers with Alkynes via C-O Cleavage
Abstract
Herein, we report a catalytic strategy that directly utilizes benzylic ethers as coupling partners through a palladium/copper cocatalyzed pathway. The reaction exhibits broad substrate scope, accommodating a wide range of functionalized benzylic alcohols and terminal alkynes, and provides direct access to valuable ynones.
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