A Direct Route to Ynones: Pd-Catalyzed Sonogashira Carbonylative Coupling of Ethers with Alkynes via C-O Cleavage

Abstract

Herein, we report a catalytic strategy that directly utilizes benzylic ethers as coupling partners through a palladium/copper cocatalyzed pathway. The reaction exhibits broad substrate scope, accommodating a wide range of functionalized benzylic alcohols and terminal alkynes, and provides direct access to valuable ynones.

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Article information

Article type
Communication
Submitted
05 Feb 2026
Accepted
24 Feb 2026
First published
24 Feb 2026
This article is Open Access
Creative Commons BY license

Chem. Commun., 2026, Accepted Manuscript

A Direct Route to Ynones: Pd-Catalyzed Sonogashira Carbonylative Coupling of Ethers with Alkynes via C-O Cleavage

W. Zhang, X. Wu, X. Qin, S. Sun, T. Xu and Z. Yin, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00779A

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