Palladium-Catalyzed Denitrative C-N Coupling of Amides with Nitroarenes Enabled by Al(OTf) 3

Abstract

We report a Pd-catalyzed denitrative C-N coupling of amide nucleophiles with nitroarenes, providing direct and atomeconomical access to N-aryl amides from readily available nitroarene feedstocks. Al(OTf)3 is essential, both promoting the reaction and suppressing BrettPhos oxidation to maintain the active Pd-phosphine species. The method shows broad amide scope and delivers products in up to 95% yield.