An unprecedented catalyst-free cyclization reaction of easily accessed enynone and unprotected hydrazine is reported. Featuring simple reaction conditions, high efficiency and broad substrate scope, this protocol provides a practical synthetic method to access various bio-related pyrazolo[5,1-a]isoquinolines derivatives in up to 82% yields using environmentally friendly solvent EtOH under air atmosphere.
Y. Mao, S. Qiu, X. Wang, Y. Shangguan, J. Liu, Z. Yang, Y. Zhao, X. Li, B. Zheng and H. Zhou, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00525J
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