From the journal:

Chemical Communications

A meso-acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo–keto reductase 1C1 in living cells

Yeri Kim,†a   Le Bich Hang Pham,†b   Jae Yeol Lee,a   Jeeyeon Lee ORCID logo *b  and  Youngmi Kim ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Research Institute of Basic Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Korea
E-mail: youngmi.kim@khu.ac.kr

b Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
E-mail: jyleeut@snu.ac.kr

Abstract

The BODIPY-based fluorogenic probe 1-CO enabled selective detection of AKR1C1 activity over related isoforms via ketone reduction, affording 50-fold fluorescence enhancement, nanomolar sensitivity, and real-time imaging in living cells.

Graphical abstract: A meso-acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo–keto reductase 1C1 in living cells

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Article information

DOI
https://doi.org/10.1039/D6CC00473C
Article type
Communication
Submitted
24 Jan 2026
Accepted
31 Mar 2026
First published
31 Mar 2026
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2026, Advance Article

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A meso-acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo–keto reductase 1C1 in living cells

Y. Kim, L. B. H. Pham, J. Y. Lee, J. Lee and Y. Kim, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00473C

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