DHA/Fe2+-doped porphyrin COFs enable ROS-amplified multimodal tumor therapy

Abstract

A porphyrin-based covalent organic framework system doped Fe2+ and dihydroartemisinin (DHA) has been developed for enhanced antitumor therapy. This platform enables coordinated generation of reactive oxygen species (ROS), including DHA-derived radicals, Fe2+-driven chemodynamic therapy (CDT), and porphyrin-mediated photodynamic therapy (PDT), which collectively amplify oxidative stress and significantly improve therapeutic efficacy.