peri-Selective C−H Activation-Initiated Spiroannulation Leading to Spiro Polycyclic Compounds with Unique Photo-Physical Property and Strong Anticancer Activity

Abstract

Presented herein is a peri-selective C−H activation-initiated spiro- annulation leading to an effective and concise construction of spirocyclic skeletons. With this reaction, benzo[de]isoquinoline spiroisoquinolinone and benzo[de]isoquinoline spironaphthalen- one derivatives otherwise difficult-to-obtain were prepared with broad substrate scope and good functional group compatibility. In addition, the products thus obtained showed unique photo- physical property and strong anticancer activity, indicating their potential to be developed as anticancer lead compounds with self-tracking capability through fluorescence detection.