Late-stage diversification of pharmaceuticals and natural products via a direct electrochemical decarboxylative platform

Abstract

We report a transition-metal-free electrochemical strategy for the late-stage diversification of pharmaceuticals and natural products via decarboxylative alkoxylation. This method directly modifies the carboxylic acid group within complex molecular frameworks, enabling the rapid synthesis of ether analogs. It exhibits broad applicability across primary, secondary and tertiary carboxylic acids.