Solid-Phase Click2 Strategy for Chromophore-DNA Conjugates and their application as Light Harvesting System

Abstract

A stepwise and orthogonal approach of two independent click reactions directly on the solid phase gives an easy access to doubly modified DNA. Firstly, 5’-ethynyl-2’-deoxyuridine reacts directly with an azide-modified porphyrin; secondly, 5’-azido-2’-deoxyuridine is generated in situ from 5’-iodo-2’-deoxyuridine, which enables the click reaction with an alkyne-functionalized pyrene. The doubly modified DNA was characterized as light-harvesting system.