From the journal:

Chemical Communications

Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy

Jianye Gong, ORCID logo †a   Yue Zhang, ORCID logo †a   Chen Lu,a   Guoyu Jiang, ORCID logo *a   Quan Jin*a  and  Jianguo Wang ORCID logo *a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, College of Green Chemistry and Environment, Institutes of Biomedical Sciences, Inner Mongolia Key Laboratory of Synthesis and Application of Organic Functional Molecules, Inner Mongolia University, Hohhot 010021, P. R. China
E-mail: jiangguoyu@mail.ipc.ac.cn, quanjin620@163.com, wangjg@iccas.ac.cn

Abstract

We develop ionic small-molecule phototheranostics by molecular engineering of positive charges and hydrophilicity/hydrophobicity balance. The optimized agent, 2PyI, achieves balanced amphiphilicity, enabling efficient NIR-II emission, reactive oxygen species generation, and photothermal conversion. It facilitates high-resolution NIR-II imaging-guided synergistic photodynamic/photothermal therapy.

Graphical abstract: Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy

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Article information

DOI
https://doi.org/10.1039/D6CC00306K
Article type
Communication
Submitted
16 Jan 2026
Accepted
11 Feb 2026
First published
12 Feb 2026

Chem. Commun., 2026, Advance Article

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Molecular engineering of ionic organic phototheranostic agents for NIR-II imaging-guided synergistic phototherapy

J. Gong, Y. Zhang, C. Lu, G. Jiang, Q. Jin and J. Wang, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00306K

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