Amphiphilic poly(aminoester) dendrimers: Click reaction-enabled synthesis, structure-governed self-assembling and degradation

Abstract

Poly(aminoester) (PAE) dendrimers are attractive materials for biomedical applications owing to their biodegradability and precise structure, provided effective synthesis and favourable safety profile. We report here a click chemistry–enabled divergent–convergent strategy for the efficient synthesis of amphiphilic PAE dendrimers. These dendrimers exhibit negligible cytotoxicity, generation-dependent degradation behaviour, and tunable self-assembly controlled by hydrophobic chain length. This study offers accessible synthesis of PAE dendrimers for advancing them in future biomedical applications.