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Chemical Communications

Nickel-catalyzed cross-electrophile-coupling of thioesters with alkyl bromides to form ketones under mechanochemical conditions

Ivo H. Lindenmaier,†a   Robert C. Richter, ORCID logo †a   Liesa Renz,a   Mattis T. Vochezer,a   Marius Schier,a   Pascal Faßnacht,a   Markus Ströbele ORCID logo b  and  Ivana Fleischer ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18, Tübingen, Germany
E-mail: ivana.fleischer@uni-tuebingen.de

b Institute of Inorganic Chemistry, Faculty of Science, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 18, Tübingen, Germany

Abstract

A solvent-minimized nickel-catalyzed synthesis of ketones, enabled by mechanochemistry, using thioesters as an acyl source is demonstrated. Mechanistic studies suggest a radical-chain-type mechanism.

Graphical abstract: Nickel-catalyzed cross-electrophile-coupling of thioesters with alkyl bromides to form ketones under mechanochemical conditions

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Article information

DOI
https://doi.org/10.1039/D6CC00297H
Article type
Communication
Submitted
15 Jan 2026
Accepted
06 Feb 2026
First published
13 Feb 2026
This article is Open Access
Creative Commons BY license

Chem. Commun., 2026, Advance Article

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Nickel-catalyzed cross-electrophile-coupling of thioesters with alkyl bromides to form ketones under mechanochemical conditions

I. H. Lindenmaier, R. C. Richter, L. Renz, M. T. Vochezer, M. Schier, P. Faßnacht, M. Ströbele and I. Fleischer, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00297H

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