From the journal:

Chemical Communications

Bioinspired Design of Ca2+ Induced Artificial Signal Transduction Systems: ON/OFF Emitting Bacteria and Excimer-FRET Signalling-Induced Bactericidal Activity

Subrata Das,   Raki Mandal,   Rahul Prakash,   Sandini P.,   Sampurna Roy  and  Pradip K. Tarafdar  

Abstract

Inspired by Ca2+-mediated loop clamping in proteins, we report an artificial signal transducer, PyLAD, featuring lithocholic acid linked to aspartic acid moiety for Ca2+ recognition and pyrene unit for signal-reporting, enabling horizontal signal transduction. Ca2+-induced assembly drives reversible ON/OFF signalling, cyan-emitting E. coli, and excimer-FRET signalling-induced inhibition of bacterial growth.

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Article information

DOI
https://doi.org/10.1039/D6CC00258G
Article type
Communication
Submitted
27 Jan 2026
Accepted
24 Apr 2026
First published
27 Apr 2026

Chem. Commun., 2026, Accepted Manuscript

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Bioinspired Design of Ca2+ Induced Artificial Signal Transduction Systems: ON/OFF Emitting Bacteria and Excimer-FRET Signalling-Induced Bactericidal Activity

S. Das, R. Mandal, R. Prakash, S. P., S. Roy and P. K. Tarafdar, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00258G

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