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Chemical Communications

Conformational Plasticity of Holliday Junctions Tunes Histone H1-Mediated Liquid-Liquid Phase Separation

Jiaqi Mao,   Yunqiang Bian,   Yang Li,   Yi Cao,   Hai Pan  and  Yanwei Wang  

Abstract

Liquid-liquid phase separation is often attributed to multivalent electrostatics, yet how DNA dynamics contribute remains unresolved. We show that Holliday junction branch-migration kinetics control histone H1-mediated condensation: H1 accelerates conformational exchange without altering equilibrium, this iontunable acceleration defines LLPS-permissive regimes, and faster junction dynamics yield more fluid condensates.

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Article information

DOI
https://doi.org/10.1039/D5CC07343J
Article type
Communication
Submitted
25 Dec 2025
Accepted
31 Mar 2026
First published
01 Apr 2026

Chem. Commun., 2026, Accepted Manuscript

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Conformational Plasticity of Holliday Junctions Tunes Histone H1-Mediated Liquid-Liquid Phase Separation

J. Mao, Y. Bian, Y. Li, Y. Cao, H. Pan and Y. Wang, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC07343J

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