Pd-catalyzed synthesis of deuterated olefins from (hetero)arenes and ketones via a cross-coupling approach

Abstract

Here, we have developed a novel, straightforward approach for the synthesis of deuterium olefins from arenes, heteroarenes, and ketones, with broad substrate scope, high yields, and excellent deuterium incorporation. The practical applications of this methodology, as demonstrated through the synthesis of deuterium-containing active pharmaceutical drugs such as bexarotene, isocombretastatin-4 (IsoCA-4), and CC-5079, aim to show its relevance and potential impact in the pharmaceutical industry.