Photochemical HAT-mediated site-selective C(sp3)–H aminoalkylation of cubanes catalyzed by TBADT

Zhicheng Tang; Mingyang Liu; Xiuran Yang; Zhuang Zhong; Sensheng Liu; Haifeng Zhou

doi:10.1039/D5CC07169K

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Photochemical HAT-mediated site-selective C(sp³)–H aminoalkylation of cubanes catalyzed by TBADT

Zhicheng Tang,^a Mingyang Liu,^a Xiuran Yang,^a Zhuang Zhong,^b Sensheng Liu

*^a and Haifeng Zhou

*^a

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* Corresponding authors

^a Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, P. R. China
E-mail: liusensheng@ctgu.edu.cn, zhouhf@ctgu.edu.cn

^b DreamChem (Tianjin) Co., Ltd., No. 4, Haitai Development 2nd Road, Binhai High-tech Zone, Tianjin, P. R. China

Abstract

Direct photocatalytic selective C–H aminoalkylation of cubanes is achieved via TBADT-mediated HAT. This radical addition strategy bypasses pre-functionalization, offering a streamlined route to valuable 3D cubane-aryl methylamine bioisosteres under mild conditions.

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DOI: https://doi.org/10.1039/D5CC07169K
Article type: Communication
Submitted: 17 Dec 2025
Accepted: 22 Jan 2026
First published: 23 Jan 2026

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Chem. Commun., 2026,62, 4059-4062

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Photochemical HAT-mediated site-selective C(sp³)–H aminoalkylation of cubanes catalyzed by TBADT

Z. Tang, M. Liu, X. Yang, Z. Zhong, S. Liu and H. Zhou, Chem. Commun., 2026, 62, 4059 DOI: 10.1039/D5CC07169K

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Chemical Communications

Photochemical HAT-mediated site-selective C(sp³)–H aminoalkylation of cubanes catalyzed by TBADT

Abstract

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Photochemical HAT-mediated site-selective C(sp³)–H aminoalkylation of cubanes catalyzed by TBADT

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