An active-template CuAAC strategy enables the efficient synthesis of (2)handcuff [2]rotaxanes in high isolated yields. A bis-2,2′-bipyridine macrocycle acts as a CuI ligand that templates dual CuAAC reactions and enforces the dual-threaded handcuff architecture. This approach provides a concise and practical route to higher-order mechanically interlocked architectures.
A. Prakash, H. Metawi and A. Saady, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC07117H
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