Glutathione polysulfides GSSSG and GSSSSG are stable in water up to 80 °C and below pH 9. Their carboxyl groups can be efficiently esterified with TMSCl in alcohols, reacting first at glycine, then glutamic acid. The resulting 3-butyne-1-yl esters allow Cu-catalyzed labeling (e.g., biotin, fluorophore) and can be hydrolyzed by esterases.
M. Yazaki, Y. Zhang, L. Zhou, R. Morise, T. Akaike and M. Arisawa, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC07029E
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