Issue 14, 2026
From the journal:

Chemical Communications

Synthesis of CF3-indene-1-ol-fused pyridones possessing potent anticancer activities through C–H activation-initiated cascade annulation under redox-neutral conditions

Shasha Ye,a   Jiayi Zou,a   Xueying Yang,a   Haiyun Xu,b   Chunhua Ma, ORCID logo *a   Xinying Zhang ORCID logo *a  and  Xuesen Fan ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China
E-mail: 2016007@htu.edu.cn, xinyingzhang@htu.cn, xuesen.fan@htu.cn

b Faculty of Chemical Engineering, Henan Technical Institute, Zhengzhou, Henan 450042, China

Abstract

Presented herein is a novel synthesis of CF3-indene-1-ol-fused pyridones through the cascade reaction of N-methoxy acrylamides with CF3-ynones.

Graphical abstract: Synthesis of CF3-indene-1-ol-fused pyridones possessing potent anticancer activities through C–H activation-initiated cascade annulation under redox-neutral conditions

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Article information

DOI
https://doi.org/10.1039/D5CC06846K
Article type
Communication
Submitted
01 Dec 2025
Accepted
14 Jan 2026
First published
16 Jan 2026

Chem. Commun., 2026,62, 4354-4357

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Synthesis of CF3-indene-1-ol-fused pyridones possessing potent anticancer activities through C–H activation-initiated cascade annulation under redox-neutral conditions

S. Ye, J. Zou, X. Yang, H. Xu, C. Ma, X. Zhang and X. Fan, Chem. Commun., 2026, 62, 4354 DOI: 10.1039/D5CC06846K

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