From the journal:

Chemical Communications

A 2nd-Generation Scalable Synthesis of the HIV-1 Entry Inhibitor CJF-III-288 Enabled by Photoredox Catalysis

Jonathan William Nadraws,   Maithili Sunil Pokle  and  Amos B. Smith III  

Abstract

The development and optimization of a 2nd-Generation process synthesis for the human immunodeficiency virus-1 entry inhibitor CJF-III-288 bis-trufloroacetate salt 1 is reported. The route eliminates the use of noble metals, decreases the step count nearly by half, and increases the overall yield tenfold.

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DOI
https://doi.org/10.1039/D5CC06802A
Article type
Communication
Submitted
30 Nov 2025
Accepted
04 Jan 2026
First published
05 Jan 2026
This article is Open Access
Creative Commons BY license

Chem. Commun., 2026, Accepted Manuscript

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A 2nd-Generation Scalable Synthesis of the HIV-1 Entry Inhibitor CJF-III-288 Enabled by Photoredox Catalysis

J. W. Nadraws, M. S. Pokle and A. B. Smith III, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D5CC06802A

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